Dr. N. Maritza Dowling

Dr. Maritza Dowling
Title:
Assistant Professor
Office:
Foggy Bottom Campus
Address:
1919 Pennsylvania Ave.
Suite 500
Washington, D.C. 20006
Phone:
202-994-0020
Email:
nmdowling@gwu.edu

N. Maritza Dowling, PhD, is an assistant professor and biostatistician at The George Washington University School of Nursing. She received a doctorate in quantitative methods with majors in statistics and psychometrics from the University of Wisconsin-Madison. Dr. Dowling’s research focuses on measurement issues in the longitudinal assessment of health constructs, patient-reported outcomes and cognitive function in older adults and the application of novel statistical approaches to model the complex interplay between risk and protective factors in dementia development and biomarkers for disease prognosis. Her research also aims to optimize cognitive outcomes measures for early diagnosis and patient selection in clinical studies of disease-modifying therapies.

Prior to joining GW, she was an associate scientist and co-director of the Biostatistics and Data Management Unit at the Wisconsin Alzheimer’s Disease Research Center where she conducted independent and collaborative methodological research designed to better understand the mechanisms underlying increased risk for Alzheimer’s disease and the neural substrates of cognitive processes and heterogeneity of changes that differentiate normal from pathological aging in asymptomatic individuals. 

For the next five years, she will serve as a co-investigator and lead statistician on a $10.8 million NIH-NIA funded study, “Prevention of Alzheimer’s disease in women: risks and benefits of hormone therapy.” This nationwide multi-site study builds on a four-year controlled randomized clinical trial Dr. Dowling previously contributed to while at Wisconsin’s Alzheimer’s Disease Research Center. The original clinical trial collected cognitive, mood and vascular risk data over four years from early menopausal women on hormone therapy; the new five-year study will follow the same population of women. The project will collect data to examine the differences in amyloid deposition, cerebrovascular lesions, cognitive function, mood and brain structure in women who were treated with different formulations of hormone therapy compared to placebo during early postmenopause.

Education

  • University of Wisconsin-Madison, Ph.D. in Quantitative Methods (2006)

Publications

Bolt, D.M., Dowling, N. M., Shih, Y-S., Loh, W-Y. Using Blinder-Oaxaca Decomposition to Explore Differential Item Functioning: Application to PISA 2009 Reading, (2017, In Press, Book Chapter). Test Fairness in the New Generation of Large-Scale Assessment.

Dowling, N. M., Bolt, D. M., Deng, S., Li, C. (2016) Measurement and Control of Bias in Patient-Reported Outcomes Using Multidimensional Item Response Theory Models. BMC Medical Research Methodology. doi: 10.1186/s12874-016-0161-z.

Dowling, N. M., Bolt, D. M., Deng, S. (2016). An Approach for Item Sensitivity to Within-Person Change Over Time: An Illustration Using the ADAS-Cog. Psychological Assessment. doi.org/10.1037/pas0000285.

Kantarci, K., Tosakulwong, N., Lesnick, T., Zuk, S., Gunter, J., Gleason, C., Dowling, N. M., Vemuri, P., Senjem, M., Shuster, L.T., Bailey, K.R., Rocca, W., Jack, C., Asthana, S., & Miller, V. M. (2016). Effects of Hormone Therapy on Brain Structure in Post-Menopausal Women: A Randomized Controlled Trial. JAMA Neurology, 38, 887-896. doi: 10.1212/WNL.0000000000002970.

Miller, V. M., Raz, L., Hunter, L., Dowling, N. M., Wharton, W., Gleason, C.; Jayachandran, M.; Anderson, L. (2016). Differential Effects of Hormone Therapy on Platelet Serotonin and Mood in Women of the KEEPS. Climacteric, 9, 49-59.

Gleason, C, Dowling, N. M., Flowers, S., Kaseroff, A., Gunn, W., Edwards, D. (2015). Common Sense Model Factors affecting African American's disclosure of symptoms of mild cognitive impairment to providers. American Journal of Geriatric Psychiatry. doi:10.1016/j.jagp.2015.08.005.

Dowling, N. M., Johnson, S.C., Gleason, C.E., Jagust, W. (2015) .The Mediational Effects of FDG Hypometabolism on the Association between Cerebrospinal Fluid Biomarkers and Neurocognitive Function. NeuroImage, 105, 357-368. 

Li, C., Dowling, N. M., & Chappell, R. (2015). Quantile regression with a change-point model for longitudinal data: An application to the study of cognitive changes in preclinical Alzheimer's disease. Biometrics. doi: 10.1111/biom.12313.

Gleason, C.E, Dowling, N. M., Wharton, W., Manson, J.E., Miller, V.M., Atwood, C.S., Brinton, E.A., Cedars, M., Lobo, R.A., Merriam, G.R., Neal-Perry, G., Santoro, N.F., Taylor, H.S., Black, D.M., Budoff, M.J., Hodis, H.N., Naftolin, F., Harman, S.M. (2015). Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS-Cognitive and Affective Study.  PLoS Medicine 2(6): e1001833. 

Gleason, C, Fischer, B.L., Dowling, N. M., Setchell, K.R., Carlsson, C.M., Asthana, S. (2015). Cognitive effects of soy isoflavones in patients with Alzheimer’s disease. Journal of Alzheimer’s Disease, 47, 1009-1019.

Almeida, R.P., Schultz, S., Austin, B., Boots, E., Dowling, N. M., Gleason, C.E., Bendlin, B.B., Sager, M.A., Hermann, B.P., Zetterberg, H., Carlsson, C.M., Johnson, S.C., Asthana, S., & Okonwo, O.C. (2015). Effect of cognitive reserve as a modifier of age-related changes in CSF biomarkers of Alzheimer's disease. JAMA Neurology, 72, 699-706.

Doherty, B., Schultz, S., Oh, J., Koscik, R., Dowling, N. M., Barnhart, T.E.,  Gallagher, C.L., Carlsson, C.M., Bendlin, B.B., LaRue, A., Hermann, B.P., Rowley, H.A., Asthana, S., Sager, M.A., Okonwo, O.  (2015). Amyloid burden, cortical thickness, and cognitive function in the Wisconsin Registry for Alzheimer’s Prevention. Alzheimer’s & Dementia: Diagnosis, Assessment, and Disease Monitoring, 1, 160-169. 

Dowling, N. M., Gleason,C.E, Manson, J.E., Hodis, H.N., Miller, V.,  Brinton, E.A., Neal-Perry, G., Santorro, N., Wharton,W., Cedars, M., Lobo, R, Merriam, G., Naftolin, F., Taylor, H., Harman, S.M., Asthana, S. (2014). Characterization of Vascular Disease Risk in Postmenopausal Women and its Association with Cognitive Performance. PLoS One, 8(7), e68741. 

Okonkwo, O., Xu, G., Oh, J., Dowling, N. M., Carlsson, C.M., Gallagher, C.L., Birdsill, A.C., Palotti, M., Wharton, W., Hermann, B.P., Larue, A., Bendlin, B.B., Rowley, H.A., Asthana, S., Sager M.A., Johnson, S. C. (2014). Cerebral Blood Flow is Diminished in Asymptomatic Middle-Aged Adults with Maternal History of Alzheimer's Disease. Cerebral Cortex, 24, 978-988.

Wharton, W., Gleason,C.E, Dowling, N. M., Carlsson, C, Brinton, E.A., Santoro, M.N., Neal-Perry, G., Taylor, H., Naftolin, F., Lobo, RA, Merriam, G, Manson, J.E., Cedars, M.I., Miller, V.M., Black, D. M., Budoff, M., Hodis, H. N., Harman, S. M. (2014). The KEEPS-Cognitive and Affective Study: Baseline Associations between Vascular Risk Factors and Cognition. Journal of the Alzheimer’s Disease, 40, 331-341.

Dowling, N. M., Olson, N., Mish, T., Kaprakattu, P., & Gleason, C. (2012). A Model for the Design and Implementation of a Participant Recruitment Registry for Clinical Studies of Older Adults. Clinical Trials: Journal of the Society for Clinical Trials, 9, 204-214.

Stricker, N., Dodge, H., Dowling, N.M., Han, D., Erosheva, E., Jagust, W. (2012). CSF biomarker associations with change in hippocampal volume and precuneus thickness: implications for the Alzheimer’s pathological cascade Brain, Imaging, and Behavior Journal, 6, 599-609. 

Hinrichs, C., Dowling, N.M., Johnson, S.C., & Singh, V. (2012). MKL-based sample enrichment and customized outcomes enable smaller AD clinical trials. Machine Learning and Interpretation in Neuroimaging (MLINI) 2011, Lecture Notes in Artificial Intelligence (LNAI) 7263, pp. 124-131.

Gleason, C.E., Dowling, N.M., Friedman, E., Wharton, W., & Asthana, S. (2012). Using predictors of hormone therapy use to model the healthy user bias: How does healthy user status influence cognitive effects of hormone therapy? Menopause, 9, 524-533.

Book chapters

 

Bolt, D.M., Dowling, N. M., Shih, Y-S., Loh, W-Y. Using Blinder-Oaxaca Decomposition to Explore Differential Item Functioning: Application to PISA 2009 Reading, (2017, In Press, Book Chapter). Test Fairness in the New Generation of Large-Scale Assessment.

Distinctions

  • Biomedical Informatics Center, School of Medicine & Health Sciences, George Washington University
  • Center for Health and Aging, Washington DC VA Medical Center
  • Center for AIDS Research (DC CFAR)